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Demolition of the long-neglected Cupples building is expected to get underway this week.
The seven-story building at 11th and Spruce was condemned in 2008 over fears it would collapse.
The last attempt to revitalize it died last week when the City of St. Louis and Vertical Realty Advisors couldn't come to terms on a $40 million plan to save the building.
Spirtas Wrecking Company will spend the next three months tearing it down. Spirtas crews plan to salvage much of the building's red brick and some of the heavy-timber frame.